Crème de la crème: Introducing L’AVENIR


*Sponsored Post*

The stylishly swish Ten Bompass Hotel was the setting for an exclusive cosmeceutical cream launch that was held on Wednesday the 14th of August 2019.

This elegant affair was hosted by Dr Sly Nedic, an anti-ageing physician and founder of the 8th Sense Medi-Spa in Sandton, where she introduced the new L’avenir Skin BHRT cream to a room full of medical professionals, scientists and anti-ageing specialists.

Dr Sly Nedic presenting L’avenir Skin BHRT

Dr Nedic explained the science behind the L’avenir range, which works on ageing skin by using the principles of integrative medicine while treating the root cause of the problem. She added that this range is the first of its kind to not only address menopausal skin and premature skin ageing in the younger population, but also the conditions where there is a deficiency in the hormone estrogen as well.

How does this product work?

During menopause, facial skin undergoes intense changes such as increased sagging, dryness and thinning, and the formation of sharp wrinkles and perioral lines. Evidence has shown that menopausal skin can lose up to 30% of collagen type I and II in the first five menopausal years, which typically corresponds to the dramatic drop in estrogen that occurs during this time.

Until now, replacing the deficient estrogen was only possible by using conventional HRT prescribed by gynaecologists, or bioidentical HRT given by functional medicine doctors. However, both have systemic effects on the whole body, which might not be suitable for some patients.

For this reason, the enthusiastic team of L’avenir-Lab has created a unique product infused with the protective estrogen, estriol, which is in the specific cream base that works locally on the skin. It is called an intradermal effect.

Futhermore, intradermal estrogen activity is a receptor-facilitated process, with evidence suggesting that the ER-beta receptor is mainly involved. These receptors have protective effects throughout the body, but in the skin, they protect against ageing and photo-damage. In other words, if these receptors are saturated with estriol, skin will appear more youthful and rejuvenated, while being protected from harmful UV radiation.

The appearance is similar to that of how most people appear in their youth – plump skin that has a slight pink colour to it and no wrinkles or sagging. This indicates that beta receptors are packed with the right amount of estrogen, which is what the L’avenir team is aiming for with this treatment.


Estrogen activity in the skin is a receptor-mediated process. The main receptor involved in this process is the Estrogen receptor beta (ER-ß) that is highly abundant in many skin structures (fibroblasts, keratinocytes, capillaries etc).

Through beta receptors Estrogen:

  • Increases collagen content
  • Increases skin cell renewal
  • Increases glycosaminoglycan’s activity
  • Influences capillary blood flow velocity and cutaneous vascular reactivity
  • Enhances wound healing
  • Increases protection from photo-damage
  • Diminishes menopausal hair loss
  • Influences sebaceous gland activity


During menopause, facial skin experiences dramatic changes such as increased laxity, dryness and thinning, wrinkles become more profound, smokers lines appear and skin becomes pale. Evidence has shown that menopausal skin loses as much as 30% of its type I and type II Collagen in the first five menopausal years.

These changes typically correspond to the dramatic drop in estrogen levels in a woman’s body.

Studies have proven that bio-identical estrogen applied topically as cosmetics significantly improves*:

  • Wrinkle depth
  • Pore size
  • Firmness
  • Elasticity
  • Skin hydration
  • Collagen type iii
  • Photo-damage protection
  • Wound healing

*all studies available on request

A2 Magazine’s Michelle Pauli was one the attendees of the launch

Where to get it?

L’avenir Skin BHRT was designed by Dr Sly Nedic and the L’avenir Lab team, and is only available from physicians specialising in aesthetic and anti-ageing medicine, dermatologists and plastic surgeons.

For more information on L’avenir Skin BHRT, visit or email


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